kppsi, I’m sorry that the effectiveness of your Rytary seems to have declined. I would suggest checking with a Movement Disorder specialist to determine if a change to the timing of your dosage needs to be adjusted. My experience is that it took some tweaking to make the Rytary work better for me. I now take 3 capsules 4x a day 4 hrs apart. Please let me know if you have found a solution to control your off times. Best,
Thea DeStephano Parkinson’s.net Community Team Member