I used rasagiline 1mg for almost a year, but when my Dr. added an antidepressant (Escitalopram), it triggered a conflict, so she switched the rasagiline to Pramipexole Dihydrochloride. I didn't notice a huge difference before the switch that made me want to get back on it, actually, I'm wanting to try levodopa/carbidopa, but can't get it in Eastern Europe.