Hi - Thanks for submitting your question. While we wait for others to chime in, I thought I'd share this article with you: https://parkinsonsdisease.net/research-studies/mannitol-sweetener-supplement/. As with any treatment or supplement, what works for one person may not work for another. We'd encourage you to discuss this with your doctor before starting any new treatments. Take care! - Chris, ParkinsonsDisease.net Team