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Serious side effects from sinemet

  • By Chris H. Keymaster

    Hi Kendall,

    I’m so sorry to hear that you’re experiencing impulse control side effects. Have you mentioned this to your doctor? Hopefully, someone from the community will respond some with some insight. Until then, we do have an article that talks about impulse control disorders here: https://parkinsonsdisease.net/living-with-pd/impulse-control-disorder/

    Thank you for commenting!
    Chris, ParkinsonsDisease.net Team Member

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  • By Karl Robb Moderator

    Hi Kendall, this is Karl Robb. I am a Community Advocate for Parkinsonsdisease.net. I have a long history with Sinemet, as I have been taking it since 1991.I am lucky that overall the drug has been very effective for me for over 25 years. It is the gold standard drug for Parkinson’s. I am not a doctor. It is my understanding that the agonists (Mirapex and Requip) are more associated with impulsive actions, but I have heard of Sinemet causing impulse issues also. Brain chemistry is very complex and it seems to react differently at different times. Predicting how someone is going to react to a medication, especially when dealing with Parkinson’s, can take try after try of finding the right medicine and dosage. Talk to your Neurologist and tell him/her what is going on. They need to know, so that they can make an adjustment to the meds! Karl Robb, ParkinsonsDisease.net Community Advocate

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  • By Michael Church

    Kendall, I’ve been taking sinemet for a better part of my 22 years of being diagnosed with PD. It has helped tremendously! At first, it made me nauseous but the more I’ve taken it, the more my body has gotten used to it. Now, I don’t have any side effects at all but then again it has become less effective. Some people just don’t tolerate medication well. Check with your neurologist if symptoms persist.

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  • By FrankMundo

    I think there may be a significant difference between those people who are “early onset” from those who are “late onset”. I have the impression from participating in various PD online support groups…. that , generally speaking, you have 4 or 5 years at best with Carbidopa Levodopa (Sinemet) before you have to augment it with other drugs and it becomes less and less effective. I wish that people would clarify which Subtype of they are (early onset or late) … as they are significantly different in longevity, effectiveness of particular drugs, incidence of dementia, etc.

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  • By Leslie

    Hi,

    I’ve been diagnosed recently in April with and PD and started carbidopa/levodopa in April as well. I have experienced nausea but no impulse control. I am having twitching and jerking of my muscles though and dystonia off my left hand and arm. Anyone having that? I just started Neupro also.

    Thanks

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  • By popuppy

    I was diagnosed in April of 1015 and at first the docs had me on the carbidopa/levadopa and it didn’t seem to last as long as it should have. Then they added Entacapone and that’s when things got strange.including impulse control disorder, constipation, digestion problems and more. So after doing a lot of research I came to the conclusion that it was the Entacapone that was causing all those issue. Sat down with my doc and we went over everything and they agreed that I should stop using Entacapone. After I stopped taking Entacapone those side affects stopped. Now the Carbidopa/Levadopa last last almost as long as they should. I get small tremors for about 15-30 minutes before my next dose which I can deal with.

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  • By BakerandShaker

    Hi everyone! I’m new to the site. I was diagnosed with early-onset PD in 2008. I was 40 years old. I was prescribed Sinemet 25/100 4x a day. It works very well for me. I have just recently had to start taking pramipexole (generic Mirapex). I think it’s been about a year and half now. My neurologist always asks me if I have been having impulse control issues, which only started after being prescribed the pramipexole. I agree with Karl that I do not believe Sinemet can cause those issues. Kendall, please talk with your doctor about it. Good luck.

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  • By hydekina

    Hi,

    I was prescribed sinemet 25/250 to take 3 times a day. I have been taking this for three months now without improvement. The patient information leaflet says 3 times a day is the starting dose.

    Is anyone here taking sinemet 25/250 more than 3 times a day?

    Is it safe to take it more than three times a day?

    I have read elsewhere that you can take sinemet 25/100 up to 8 times a day. Does that apply to sinemet 25/250?

    Thanks for your response.

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    • By Chris H. Keymaster

      I’m sure that’s frustrating, @hydekina. If you haven’t already, these would be great questions to bring up during your next doctor/neurologist appointment. Unfortunately, we are not medical professionals and cannot provide medical advice for your safety. In the meantime, I thought I’d share some information about carbidopa/levodopa here: https://parkinsonsdisease.net/medications/carbidopa-levodopa-therapy/. Keep us updated! – Chris, ParkinsonsDisease.net Team

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    • By Leslie

      Hi,

      I also started on the same dose and strength of sinemet as you. That was over 2 years ago. Since then I’ve been increased to one pill of carbidopa/ levodopa 25/100 every 3 hours: 7:30, 10:30, 1:30, 4:30 and 7:30pm. I also take Neupro patch 2mg daily. At first I had some lightheartedness and orthostatic hypotension but I have adjusted to it now and seem to be able to function pretty well. I do get some tremor back if I forget a pill so I set an alarm on my phone. At first I experienced nausea, dystonia and dyskinesia but most of that has stopped.

      Hope this helps but do talk to your neurologist about all of this.

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    • By Chris H. Keymaster

      Good to hear from you, Leslie! Thanks for providing your insight. Hope you’re doing well. – Chris, ParkinsonsDisease.net Team

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