Skip to Accessibility Tools Skip to Content Skip to Footer
Causes & Treatments of Bowel Issues with Parkinson’s Disease

Causes & Treatments of Bowel Issues with Parkinson’s Disease

They say the gut is the second brain in our bodies because of all the complex neuronal connections it possesses. Furthermore, the latest theory is that PD may have its origins in the gut and then migrates into the brain.

Whether the dysfunction in PD began first in the brain or in the gut, one thing is for sure when the gut is unhappy not only is the person suffering GI symptoms miserable but consequently everyone around tends to be unhappy due to the mood altering behavior having a sick gut places on an individual.

Recently, I was doing an interview about Parkinson’s troublesome issues and I had to admit that by far my most troublesome and annoying problem is related to the effects of my gut. This is true for the majority of us living with this disease. Whether it be a direct or indirect consequence of our illness is irrelevant in my opinion when the effect is the same. Plus to be honest I am not sure anyone of us can tell the difference most of the time.

As I have re-discovered the agony of suffering from one of these ailments over the last several months when I had several bouts of ileus. In my opinion, there is nothing worse than having stomach pain, bloating, nausea, indigestion, and gas to make life miserable.

Below are all the plausible GI symptoms all of us can experience throughout our journey with PD.1 The most common symptoms are those related to poor motility or dysmotility and can be compounded by the effect of the medication.


First many patients with PD have migraines and with the involvement of the brainstem and serotonin region this was to be expected. Further many of the medications cause nausea because dopamine is very irritating to the gut. Of course the medications particularly the levodopa compounds may trigger migraines worsening migraines. Nausea associated with medications typically subsides for most people or lessens dramatically within a week. Ginger tea works well.

Gerd – reflux/heartburn

This happens because of the effect of medication; also because of poor motility. Food tends to want to return or does not move down causing it to be stuck in the esophagus. Make sure that you see a specialist rule out infection with H. Pylori which if present, will also make your medication work less effectively.


This is the one symptom we are fixated on but in reality is a combination of all the GI symptoms that cause us the most trouble in our daily life. The thing I have found to have the biggest impact is diet including no raw vegetables, hard to digest legumes, high gas foods like beans, fruits with skin, and heavy greasy foods particularly late in the evening. Some suggest to eat small frequent meals and not eating past 5 PM. This is extremely hard for me to do when I am with family. Avoid doing laxatives because these can cause heart, kidney and hypokalemia problems as well as build up a tolerance and stop working faster than some of the other ones recommended. There are also medicines like lactulose, Miralax, fiber supplements and stool softeners but I personally find that these cause a lot of gas build-up which can be embarrassing but also not very good for daily use in most people. There are also other OTC treatments like probiotics which can help but just make sure you rotate various brands and do not take if it causes chills or fever. If you are already experiencing an illness or have a compromised immune system like me it is best not to take these. If needed, seek the help of a GI specialist.


Sometimes when the function becomes so slow the movement is imperceivable causing everything to stop. The result is no bowel movements, severe nausea, abdomen bloating and even throwing up. Seek attention immediately. To prevent, drink peppermint or mint tea.


Sometimes when constipation is severe it can lead to a blockage. Make sure to seek immediate help if you have not voided in more than 3 days especially if painful abdomen or no response to usual laxatives.

Enuresis (incontinence of stool)

The main cause of this is severe constipation which causes leakage. Be sure to have back up undergarments and change of clothes or use disposable undergarments if traveling, do not have accessible restrooms, or are unable to move quickly to go to the bathroom.

All of these can not only make life difficult but more importantly, worsen our PD symptoms by preventing the proper delivery of the oral medication. Some of the things that work for me to avoid some of these issues is having different types of delivery systems to avoid overwhelming my gut. Above all, I try to maintain a proper bowel regimen along with frequent visits to the GI specialist, which means allowing yourself time to void daily and not ignore the urge. Also when you feel that you are not passing gas at all go to the doctor and experts suggest to drink only liquids when severely constipated – things like Gatorade, Jell-O, clear liquid, bouillon chicken soup, Sprite, Seven Up, or ginger ale (I have started doing this once a week to help cleanse the system).

This article represents the opinions, thoughts, and experiences of the author; none of this content has been paid for by any advertiser. The team does not recommend or endorse any products or treatments discussed herein. Learn more about how we maintain editorial integrity here.

  1. Holden K. Parkinson's Disease and Acid Reflux - Nutrition U Can Live With. Nutrition U Can Live With. Published 2016. Accessed January 23, 2019.
  2. Çamcı G, Oğuz S. Association between Parkinson's Disease and Helicobacter Pylori. Published 2016. Accessed January 23, 2019.
  3. Bronstein MD PhD J. Helicobacter Pylori Eradication and Motor Fluctuations in Parkinson's Disease. The Michael J. Fox Foundation for Parkinson's Research | Parkinson's Disease. Published 2007. Accessed January 23, 2019.
  4. Jost W. Gastrointestinal Motility Problems in Patients with Parkinsonʼs Disease
  5. Colonic Dysmotility - Parkinson Disease - ALPF Medical Research. Published unknown. Accessed January 23, 2019.


  • Maria De Leon author
    12 months ago

    Nepper. Thank you for your problems rule my life as well still trying to figure out the best course of action which seemed to be small meals 4 times a day but no later than 7 …Glad you found something that works ..have good day Maria/ moderator/ author and patient advocate

  • nepper
    12 months ago

    Thank you for a very informative article on this debilitating condition. In my case – Gastrointestinal suspicions were the main focus for almost 24 months prior to neurological investigations and diagnosis. GI still rules my life 110% although the introduction to TAI (Trans Anal Irrigation) has had a profound and positive effect on quality of life.

  • DavidStone
    12 months ago

    I have exactly the opposite problem; constant diarrhea. This has been a minor problem for 20+ years since I had bariatric surgury, but has become a much larger problem in the 2.5 years since my introduction to my new friend, Mr. P.

    While usually manageable, I am sometimes taken by surprise or am not in a situation where a bathroom is immediately available. Oops!

    Does anyone else have this problem or am I the only one wishing for Parkinson’s-related constipation?

    Since my medical care comes through the VA who, BTW, has been very accommodating and easy to deal with since my diagnosis, we are sort of treading new ground here. My Neurologist is a bit baffled and is seeking advice from a bariatric specialist, who understandably, isn’t well versed in the peculiarities of PD. So far, no relief is in sight, but we are still seeking a “middle ground”.

    Has anyone else encountered this particular phenomenon, and if so, is there any viable solution other than buying anti – diarrheals in bulk?


  • Maria De Leon author
    12 months ago

    i am sorry to hear you are having this problem. in my experience diarrhea is a common side effect of bariatric surgery usually known as dumping syndrome. In PD i am not aware of diarrhea except that related to the comt inhibitor medications i.e tasmar, comtan and the new one opicapone. sometimes when people have severe constipation however they can experience leakage and inability to hold stool. please discuss with your physician to make sure no other medical causes or if related to pd meds. take care. author/advocate/moderator-Maria De Leon

  • DavidStone
    12 months ago


    As I understand “dumping”, it is most often caused by the ingestion of sugar. I learned early on to read labels for “hidden” sugar and avoid it like the plague. Nonetheless, I’ve suffered from loose stool since the beginning. I don’t believe that any of my PD medications are contributing factors at this point. I just wish there was some “magic bullet” that would help. I do bring it up occasionally with my Dr. but don’t get much traction once I mention the bariatic surger. I’ll keep trying to find a sympathetic medical ear, but in the meantime I’ll continue plotting the locations of the nearest restrooms and carry “spares”.


  • Poll